Ultra-Resilient Nanovesicular Systems: as a Novel Tool in Successful Transdermal Drug Delivery

Pandey Vikas*, Shukla Ajay, Golhani Dilip, Shukla Rajesh 

Guru Ram Das Khalsa Technology & Science, Jabalpur 

ABSTRACT

Skin is always been an area of interest as a port of entry for the systemic delivery of various therapeutic agents and drugs as it deciphers the number of problems allied with oral route of drug administration but it is also fabricated with a complex barrier of stratum corneum which acts as a impending snag for passage of macromolecular /hydrophilic /ionizable bioactives. Various strategies have been developed in to resolve this issue like transcuteneous iontophoresis, microneedles, chemical permeation enhancers, electrophoresis, sonophoresis, vesicular systems (liposomes) etc, out of these one transferosomes emerges out as a promising approach. Transferosomes are novel vesicular system that are several time more flexible than conventional vesicular system consisting of Phospholipids, edge activators and ethanol which can be applied in non-occlusive manner, in regard to their ability of having deformation they can potentially deliver the therapeutic agents in non-invasive and non-allergenic manner. The present review article presents an exhaustive account on how transferosomes is an emerging tool in transdermal drug delivery systems.

Keywords: Deformable vesicles, transferosomes, transdermal, drug delivery.