DOI:

ISSUE 2, FEB 2013

Probable anxiolytic mode of action of syzygium cumini seed extract

Nagar Hemant , Pandey Ranjana  and Mishra Aditya 

Sapience Bio-analytical Research Lab., Bhopal

ABSTRACT

An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms. Syzygium cumini (Family- Myrtaceae) is one of the widely used medicinal plants in various diseases like diabetes, inflammation and CNS related diseases. Hence the present study was aimed to find out the anti-anxiety effects of aqueous and ethanolic extract of Syzygium cumini seed and its probable mechanism of action. Both the extract at the dose of 200mg/kg was evaluated for anti-anxiety activity by elevated plus maze (EPM) test and Light-Dark test. Probable anxiolytic mode of action through GABAergic neurotransmission and serotonergic neurotransmission was elucidated by comparing Diazepam and Fluoxetine respectively. Ethanolic extract was produced significant anxiolytic effect. The mechanism of anxiolytic action of ethanolic extract of Syzygium cumini was found involvement of GABAergic transmission.

Keywords: Anxiolytic, GABAergic Neurotransmission, Serotonergic Neurotransmission, Syzygium cumini


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