Design, synthesis and anti-inflammatory activity of substituted Chromones

Vishal Gupta^{1, 2} and S. K. Yadav³*

Ravishankar College of Pharmacy, karod, near peoples hospital, Bhopal   

ABSTRACT

The Chromones and other related ring systems have several interesting biological activities such as anti-inflammatory effects. Chromones also having anti-bacterial and antifungal activities from heterocyclic substituents at 2- position and exhibit good phosphodiesterase-IV inhibition activity and some chromones have potential HIV- inhibition activity as well as Spiro amine derivatives having anti-arrhythmic activity. Performed reaction having catalyzed Claisen rearrangement SnCl4 of allyl aryl ethers followed by cyclization gives oxygen hetrocycles. By utilizing SnCl4 as lewis acid the rearragment reaction is affected under mild condition. The anti-inflammatory activity of the synthesized compounds was determined by rat paw edema method. Some of the compounds were found to be potent.

Keywords: Chromones, inflammation, melting points, NMR, IR