Nanosponges: A Novel Approach of Drug Delivery System

A. R. Thakre*, Y. N. Gholse, R. H. Kasliwal

Department of Pharmaceutics, Priyadarshini J. L. College of Pharmacy, Maharashtra, India

ABSTRACT

Targeted drug delivery to specific sites is the significant problem which is being faced by the researchers. The development of new colloidal carrier called nanosponges has the potential to solve these problems. Nanosponge is a novel and emerging technology which offers controlled drug delivery for topical use. In this review article, application of nanosponges, its preparation methods by Emulsion solvent diffusion method, and by using hyper crosslinked cyclodextrin and evaluation have been discussed. Nanosponge play vital role in targeting drug delivery in a controlled manner. Both lipophilic and hydrophilic drugs are incorporated in nanosponge. The outer surface is typically porous, allowing controlled release of drug. They enhanced solubility, bioavailability reduce side effects and modify drug release. Nanosponge drug delivery system has emerged as one of the most promising fields in life science used in chemotherapy nowadays

Keywords: Nanosponges, topical application, polymers, targeted drug delivery, controlled drug delivery