1*Chowrasia Deepak; 1Sharma Nisha; 2Arshad Md.; 3Viswanadham K.K Durga Rao

DOI:

VOLUME-5, ISSUE-9

A MODIFIED CLAISEN-SCHMIDT PROTOCOL FOR SYNTHESIS OF 1,3-DIARYL-2-PROPEN-1-ONE (CHALCONE)

1*Chowrasia Deepak; 1Sharma Nisha; 2Arshad Md.; 3Viswanadham K.K Durga Rao

1. University Institute of Pharmacy, CSJM University, Kanpur, U.P.-208024, India

2. Moleular Endocrinology Lab, Department of Zoology, Lucknow University, Lucknow, U.P-226007, India

3. Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow, U.P.-226031, India

ABSTRACT

We here reports a modified improved method for synthesis of 1,3-diaryl-2-propen-1-one, rely on base catalyze condensation of arylmethyl ketone with aromatic aldehyde. This method however to an extent analogues to classical methodology thou minute changes in reactant charging sequence, prominent control over their dropping rate, and strict temperature regulation enhance its synthetic utility.

Keywords: Chalcone, Claisen-Schmidt condensation, synthetic tool, eco-handy technique

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