Synchronous and Controlled Conveyance of Metformin Hydrochloride and Glipizide Controlled Porosity Osmotic Pump in-vitro Quantification

Subashini Rajaram, Jamuna B, Senthil Rajan D

Department of Pharmaceutics and Research Swamy Vivekanandha College of Pharmacy, Tiruchengode, Namakkal, Tamilnadu, India

ABSTRACT

In the current research, controlled porosity osmotic pump (CPOP) tablet is prepared by direct compression method and the tablet coating was achieved by a dip-coating process using chitosan as conveyance retardant to decrease the burst release time of Metformin HCl (MTF), sodium hydrogen carbonate as pH modifier and Hydroxy Propyl Methyl Cellulose (HPMC) E 15 LV as hydrophilic polymer to improve the appearance of Glipizide (GLZ) to pass on the blend of MTF and GLZ in a kept up and synchronized way. The prepared tablets were characterized for its release. The release data was fitted with release kinetics in order to determine order of release and release mechanism. The impact of release retardant shows that there is no blasted delivery of MTF was noticed upto 4th h and the delivery was controlled up to 24h and the delivery pace of GLZ was improved while joined with MTF and sodium bicarbonate. In conclusion, this methodology could be gainful for the treatment of diabetes mellitus Type 2 (DMT2) with improved disintegration.

Keywords:

Controlled porosity osmotic pump, Diffusion mechanism, Glipizide, Metformin HCl, Release retardant