Formulation and evaluation of controlled release metoprolol succinate matrix tablet using natural waxes for the management of hypertension

Nikhil Wasekar, Vinod Thakare, Kishor Danao, Monali Dumore

Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India

ABSTRACT

Metoprolol succinate is a cardioselective β-blocker used in the management of secondary hypertension complications. Metoprolol succinate is prescribed to suppress the hypertension condition and to minimize the cardiac-related disorder. In the present study, metoprolol succinate sustained-release tablets were successfully prepared by the wet granulation method. Carnauba and beeswax as natural resources were used as drug release modifying polymers in varying ratios of 1:0, 0:1, and 1:1 respectively. All developed tablets were passed the uniformity of weight, friability, uniformity of thickness, and uniformity of diameter test respectively. The crushing strength of formulated tablet was in ranges of 1.4 to 2.4megapascal (MPa) and showed the optimum tensile strength. The formulated tablet's percentage of drug content and content of uniformity had97.50 and 99.24.The formulated batch F3 (ratio of 1:0) which are capable for provide the desirable drug release over a twelve hours period. The stability study shows the formulation batch F3 was stable. Therefore, this formulation method is economically it may be suitable for the pharmaceutical industries to use this type of simple technology for the development of advanced formulations.

Keywords:

Metoprolol succinate, Carnauba wax, Beeswax, Sustained release tablet, Matrix tablet, Polymer ratio