Archaeosomes for both cell-based delivery applications and drug-based delivery applications

Ajay G Pise, Shilpa A Pise

Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra, India

ABSTRACT

Archaeosomes, or liposomes produced with one or more Archaeobacteria-specific ether lipids, are a novel kind of liposome found in Archaea. The fundamental structures of Achaean-type lipids are archaeol (diether) and/or caldarchaeol (tetraether). To make archaeosomes at any temperature in the physiological range or lower which enable thermally stable compounds to be encapsulated, traditional procedures like hydrated film sonicated, extrusion, and detergent dialysis are used. A multitude of physiological and environmental factors impact its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery, and administration of natural antioxidant compounds. The major purpose of this study was to look at how this unique carrier technology may be used in the pharmaceutical industry.

Keywords:

Archaeobacteria, Archaeosomes, Cell Delivery, Drug Delivery, Gene Delivery, Formulations