Damage-associated molecular patterns & m2 microglial polarization in Parkinson’s disease - A brief review

Umair Wahedi, Mohammad Zubair Baba, Thaggekuppe Krishnamurthy Praveen, Gomathy Subramanian

Department of P’ceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Res., Ooty, Nilgiris, Tamil Nadu India

Refer this article

Umair Wahedi, Mohammad Zubair Baba, Thaggekuppe Krishnamurthy Praveen, Gomathy Subramanian, 2022. Damage-associated molecular patterns & m2 microglial polarization in Parkinson’s disease - a brief review. Journal of Medical Pharmaceutical and allied Science V 11 - I 5, Pages - 5289 – 5297. Doi: 10.55522/jmpas.V11I5.4015.

ABSTRACT

Neuroinflammation is an essential player in the progression of Parkinson’s disease and other neurodegenerative disorders, according to post-mortem findings. Ligands that contribute to Neuroinflammation are Pathogen-associated molecular patterns and damage-associated molecular patterns that bind to Pattern Recognition Receptors and immune receptors, causing inflammation and additional neuritis damage. Glial cells play a vital role in Neuroinflammation; they create a range of complex structures in the brain that help maintain homeostasis and defenses; among neuroglia cells, microglia in response to noxious stimuli polarizes into microglial inflammatory phenotype 1 or microglial immunosuppressive phenotype 2 responses. Therapeutic opportunity exists by regressing microglial inflammatory phenotype 1 polarization and boosting microglial immunosuppressive phenotype 2, thereby decreasing inflammatory assault by limiting pro-inflammatory agents and encouraging anti-inflammatory response.

Keywords:

Neuroinflammation, Parkinson’s disease, DAMPs, Microglial polarization, M2 microglia, PRR

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