In-silico exploration of piperine for invent proton pump and protein phosphatase non-receptor Inhibitors in gastric and peptic ulcer

Bhusnure Omprakash G, Ware Shrinivas V, Jadhav Harshada P, Bansode Prashant S, Gholve Sachin B, Giram Padmaja S

Department of Pharmaceutical Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Refer this article

Bhusnure Omprakash G, Ware Shrinivas V, Jadhav Harshada P, Bansode Prashant S, Gholve Sachin B, Giram Padmaja S, 2022. Insilico exploration of piperine for invent proton pump and protein phosphatase non-receptor inhibitors in gastric and peptic ulcer. Journal of medical pharmaceutical and allied science V 11 - I 6, Pages - 5334 – 5338. Doi: 10.55522/jmpas.V11I6.1865.

ABSTRACT

Anti-ulcer medicines that inhibit the H/K-ATPase enzyme by covalently binding to a cysteine residue of proton pump inhibitors. Through the aforementioned processes, tyrosine-protein phosphatase non-receptor type 11 (PTPN11) causes aberrant mitogenic signals and elongated morphological alterations, as well as the growth and progression of peptic ulcer and gastric cancer.Piperine is an antioxidant derived from the Piper Longum herb. Molecular docking studies and virtual screening were used to investigate it as an H/K ATPase and PTPN11 inhibitor. The Molecular Docking examination was conducted using the Pyrx 0.8 version free database, while virtual screening was conducted using Biovia Discovery Studio software.H/K-ATPase and PTPN11 have substantial binding affinity of 7.5 and 8.6 kcal/mol, respectively, according to molecular docking investigations. Piperine's anti-ulcer efficacy appears to be aided by H/K-ATPase and PTPN11 binding.

Keywords:

Proton Pump inhibitors, H/K-ATPase, PTPN11, Molecular Docking, Virtual Screening, Ulcer, Piperine

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