In silico analysis of green tea catechins for design of adenosine A2A antagonist and nav 1.7 inhibitors

Jadhav Harshada P, Bansode Prashant S, Gaikwad Varsha M, Gholve Sachin B, Giram Padmaja S

Department of Pharmaceutical Quality Assurance, Channabasweshwar Pharmacy College Latur, Maharashtra,, India

Refer this article

Jadhav Harshada P, Bansode Prashant S, Gaikwad Varsha M, Gholve Sachin B, Giram Padmaja S, Bhusnure Omprakash G, 2022. In silico analysis of green tea catechins for design of adenosine A2A antagonist and nav 1.7 inhibitors. Journal of medical pharmaceutical and allied sciences, V 11 - I 6, Pages - 5389 – 5399. Doi: 10.55522/jmpas.V11I6.1844.

ABSTRACT

Neuropathic pain is a sensory nerve system disorder that affects a large percentage of the world's elderly population. A sensory nerve system injury causes it, which can lead to function loss, acute discomfort, and heightened pain sensitivity. The PNS is in responsible of the start and maintenance of Neuropathic Pain, despite the fact that the CNS is the major controller of pain. Diseases like diabetes and cancer are connected to a change in lifestyle in today's globe. Concentrating compounds that can boost neurotransmitter release can be used to treat these disorders. Adenosine receptors and sodium channels are the next targets for inflammatory and peripheral neurological diseases.Green tea contains antioxidants such as catechins, EC, EGC, ECG, EGCG, GC, CG, GCG, GCG3ME, ECG3Me, EGCG3Me, and EGCG4Me. This research describes how molecular docking and virtual screening were used to assess the binding potential of green tea catechins for human adenosine A2A receptors and sodium channel Nav 1.7 inhibitors. As a result, a number of Green Tea Catechins exhibit exceptional binding abilities.

Keywords:

Green Tea Catechins, Adenosine A2A, Nav 1.7, Molecular Docking, Virtual Screening

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