Drug induced nephrotoxicity and associated factors a narrative review

Nagalakshmi N, Manju V., Basavaraj Poojar, Ravi K. Sori, Amrita Parida

Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India

Refer this article

Nagalakshmi N, Manju V., Basavaraj Poojar, Ravi K. Sori, Amrita Parida, 2023. Drug induced nephrotoxicity and associated factors a narrative review. Journal of medical pharmaceutical and allied sciences, V 12 - I 1, Pages - 5563 – 5570. DOI: 10.55522/jmpas.V12I1. 4171.

ABSTRACT

Drugs are a common reason for kidney injury. Antibiotic like gentamicin which is clinically a highly effective drug, is not preferred by physicians primarily because of the renal damage caused by it. Medication-induced renal injury has an intricate mechanism that includes a multitude of elements together with the innate nature of medications, innate patient characteristics that increase the chances of renal damage, and the pharmacokinetics of the drug. A particular drug can produce varied amount of damage in different individuals, which implies that the risk is not same for all. The reason behind this is that, there are different factors which determine the amount of renal damage that occurs due to drugs. In this article, we have reviewed the various elements linked to drug-induced nephrotoxicity.

Keywords:

Renal Damage, Reno-Toxins, Kidney Damage, Medicine.

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