Synthesis and anti-inflammatory activity of 2-amino-4,5-diphenyl-1-(substituted)-1H-pyrrole-3- carbonitrile derivatives

Sandip P. Dholakia, Mukesh N. Kher, Dipen K. Sureja, Devang B. Sheth, Amitkumar J. Vyas

L. M. College of Pharmacy, Ahmedabad, Gujarat, India.

Refer this article

Sandip P Dholakia, Mukesh N. Kher, Dipen K Sureja, Devang B. Sheth, Amitkumar J. Vyas, 2023. Synthesis and anti-inflammatory activity of 2-amino-4,5-diphenyl-1-(substituted)-1h-pyrrole-3-carbonitrile derivatives. Journal of medical pharmaceutical and allied sciences, V 12 - I 1, Pages - 5613 – 5617. DOI: 10.55522/jmpas.V12I1.4452.

ABSTRACT

Pyrrole is privileged and active heterocycle with diverse pharmacological activities that specifically serve as a promising scaffold for antiinflammatory, antimalarial, antimicrobial, antiviral, antitubercular, and enzyme-inhibiting drugs. In an attempt to explore this scaffold, a series of 2-amino-4,5-diphenyl-1-(substituted)-1H-pyrrole-3-carbonitrilewere synthesized and screened for anti-inflammatory activity. The structures of synthesized novel compounds were characterized by 1H Nuclear Magnetic Resonance, Mass and Fourier Transfer Infrared spectroscopic data. All the compounds are screened for anti-inflammatory activity using the rat paw edema method. Among all, compound 1e exhibited more potent activity than the standard drug etoricoxib with the highest inhibition in paw edema at 3 hours and 5 hours.

Keywords:

Anti-inflammatory, Etoricoxib, Pyrrole, Antiviral, Antimalarial

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