Antidepressant and anxiolytic effects of melaleuca cajuputi essential oil on chronic immobilization stress (CIS)-Induced mice model

Arif Azimi Md Noor, Rasmaizatul Akma Rosdi, Mohd Dasuki Sul'ain, Wan Nor Amilah Wan Abdul Wahab, Wan Rosli Wan Ishak

Programme of Nutrition and Dietetics, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

Refer this article

Arif Azimi Md Noor, Rasmaizatul Akma Rosdi, Mohd Dasuki Sul'ain, Wan Nor Amilah Wan Abdul Wahab, Wan Rosli Wan Ishak, 2023. Antidepressant and anxiolytic effects of melaleuca cajuputi essential oil on chronic immobilization stress (CIS)-induced mice model. Journal of medical pharmaceutical and allied sciences, V 12 - I 1, Pages - 5653 – 5661. DOI: 10.55522/jmpas.V12I1.4686.

ABSTRACT

The preliminary studies showed that Melaleuca cajuputi essential oil (MCEO) contained several phytochemicals of antidepressant and anxiolytic properties. Therefore, the aim of this study is to evaluate the antidepressant and anxiolytic effects of MCEO on chronic immobilization stress (CIS)-induced mice.Eight groups of male Swiss albino mice were divided into control, CIS+DMSO, CIS+amitriptyline and CIS+MCEO at different concentrations (1, 2.5, 5, 7.5 and 10% v/v). All mice groups except the control were subjected to a 2-hours CIS procedure for 15 days. All MCEO treatments were administered through the inhalation route, while the amitriptyline was via intraperitoneal from day 16 to 20. The anxiolyticandantidepressant effects of MCEO were evaluated via behavioural tests, histopathological changes and corticotrophin-releasing hormone (CRH) level on day 21. Results were analysed using one-way ANOVA followed by Dunnet’s posthoc test with the significant level of P<0>

Keywords:

Anxiety, Depression, Essential Oil, Inhalation, Melaleuca Cajuput, Swiss Albino

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