Quantitative analysis of favipiravir in bulk and pharmaceutical dosage forms using UV visible spectrophotometer

Karthikeyan Ramadoss, Semmal Syed Meerasa, Ankit Kumar Swastik Satyapal, Abishek Vijayakumar, Vijayan Venugopal

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India.

Refer this article

Karthikeyan Ramadoss, Semmal Syed Meerasa, Ankit Kumar Swastik Satyapal, Abishek Vijayakumar, Vijayan Venugopal, 2023. Quantitative analysis of favipiravir in bulk and pharmaceutical dosage forms using UV visible spectrophotometer. Journal of medical pharmaceutical and allied sciences, V 12 - I 2, Pages - 5680 – 5683. Doi: 10.55522/jmpas.V12I2.4410.

ABSTRACT

The main aim of this study is to develop a rapid and cheap Ultraviolet (UV) spectrophotometric method for the estimation of Favipiravir (400mg) in tablets and validate as per International Conference on Harmonization (ICH) guidelines. The developed method uses the solvent Ethanol: Water (30:70) for the assay of Favipiravir whose λmax was found to be 231nm. In this method, Favipiravirshows linearity in the range 2-10 μg/ml. The accuracy was carried out by using standard addition method and the precision is ascertained by calculating the relative standard deviation. A cheap and rapid UV spectrophotometric method was developed and validated for the estimation of Favipiravir and hence it can be used for the routine pharmaceutical analysis.

Keywords:

Favipiravir, Validation, ICH, UV spectrophotometer, Assay.

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