Vaginitis phyto therapy against vaginal pathogen and molecular identification of isolated vaginal pathogen

Varalakshmi B, Jannathul Firdous, Karpagam T, ShanmugaPriya A, Suganya V, Revathi S

Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Jalan Greentown, Ipoh, Perak, Malaysia

Refer this article

Varalakshmi B, Jannathul Firdous, Karpagam T, ShanmugaPriya A, Suganya V, Revathi S, 2023. Vaginitis phytotherapy against vaginal pathogen and molecular identification of the isolated vaginal pathogen. Journal of medical pharmaceutical and allied sciences, V 12 - I 2, Pages - 5762 – 5767. Doi: 10.55522/jmpas. V12I2.4056.

ABSTRACT

Female genital tract infections are major public health problems, with considerable economic consequences. Drugs like metronidazole and clindamycin are unable to control the growth of vaginal infection completely, which requires alternate novel treatment strategies. Some herbal antimicrobial agents are reported to inhibit the growth of vaginal infection. Boerhaavia diffusa andAzadirachta indica are such herbs with antimicrobial, antioxidant and anti-inflammatory properties. In the present study, vaginal fluid samples from infected patients were collected and cultured using different media. Isolated pathogens were identified using 16S rRNA sequence. Four bacterial pathogens were isolated and identified. The pathogens identified were Aeromonas cavia, Lactobacillus, Staphylococcus aureus and Klebsiella pneumomiae. Anti-vaginalis activity of the two herbs were analysed in an isolated pathogen. Maximum zone of inhibition was observed against S. aureus and Aeromonas caviae. The present investigation confirmed that, Boerhaavia diffusa andAzadirachta indica herbal extracts were able to control the vaginal pathogens without any side-effects.

Keywords:

Biochemical analysis, Bacterial pathogens, Phytochemicals, 16S rRNA sequence, Vaginitis.

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