Novel 1,3,4-Oxadiazole Hybrids with Antitumor and Anti-proliferative Potentials: A Comprehensive Review

Tarun Chaudhary, Prabhat Kumar Upadhyay*, Deepak Prashar, Vivek Kumar, Sahil Kumar

Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India

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Prabhat Kumar Upadhyay, Tarun Chaudhary, Deepak Prashar, Vivek Kumar, Sahil Kumar, Novel 1,3,4-Oxadiazole Hybrids with Antitumor and Anti-proliferative Potentials: A Comprehensive Review. Journal of medical pharmaceutical and allied sciences, V 12 - I 4, Pages - 5939 – 5948. .Doi:https://doi.org/10.55522/jmpas.V12I4.4429.

ABSTRACT

Cancer is a lethal illness, and research into the development of effective anti-cancer medications is ongoing at all hours of the day and night. This is where 1,3,4-oxadiazoles come into play, since they are privileged and authenticated compounds because of their anti-cancer capabilities. In the field of drug development, 1,3,4-oxadiazole entities are characteristic heterocyclic rings with dominant anti-cancer activities. As a result, the primary goal of this article is to review the synthesis and screening of new 1,3,4-oxadiazole powerful derivatives is to determine their anti-cancer, antitumor, and other potential applications in the creation of anti-neoplastic drugs. In this study, the focus is on the 1,3,4-oxadiazole hybrids as well as the most significant bioactivity and potentiality of these anti-cancer compounds. This review article will include references to significant current reviews in the material, as well as a relevant discussion on the general background of anti-cancer medications that include 1,3,4-oxadiazole hybrids.

Keywords:

1,3,4-Oxadiazole, Anti-cancer, Antitumor, Antiproliferative, Heterocycle, Activities.

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