Investigating the influence of lipids on nano-structured lipid carrier formulation

Brito Raj S, Akilandeswari S, Lakshmi K, Venkateshwaran K, Uma Devi, Shaheedha

School of Pharmacy, Dhanalakshmi Srinivasan University, Samayapuram, Trichy, Tamilnadu, India.

Refer this article

Brito Raj S, Akilandeswari S, Lakshmi K, Venkateshwaran K, Uma Devi, Shaheedha, 2023. Investigating the influence of lipids on nanostructured lipid carrier formulation. Journal of medical pharmaceutical and allied sciences, V 12 - I 6, Pages - 6147 – 6154. Doi: https://doi.org/10.55522/jmpas.V12I6.5220.

ABSTRACT

The study aimed to evaluate the effect of different lipids on the properties of nanostructured lipid carrier (NLC) formulations. The particle size, zeta potential, polydispersity index, entrapment efficiency, and drug release at 24 hours were analyzed for formulations containing various lipid matrices. Among the formulations tested, N3 (Compritol 888 ATO and Softigen) exhibited the most favourable characteristics, including the smallest particle size, highest entrapment efficiency, sustained drug release, and good stability, as indicated by a high negative zeta potential. Other lipids, such as Witepsol H 32 and Beeswax, also showed desirable properties. The formulations containing Dynasan 114 and Acconon-C-44 EP/NF resulted in larger particle sizes, lower entrapment efficiencies, and slower drug release. Cholesterol exhibited distinct properties, with a lower negative zeta potential and moderate drug release. The findings highlight the importance of lipid selection in determining the performance and functionality of NLC formulations. Compritol 888 ATO and Softigen were identified as suitable lipids for further optimization of NLC formulations. These lipids contribute to the formation of stable and uniform NLC particles, which are desirable for efficient drug delivery systems. The study provides valuable insights for formulating NLCs with optimized characteristics, facilitating the development of effective drug delivery systems. Future research can focus on optimizing other factors to enhance the performance and therapeutic effectiveness of NLC formulations.

Keywords:

Nanostructured Lipid Carrier, Surfactant, Hot homogenization technique, Particle size, Zeta potential.

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