Potential of bovine lactoferrin as an inhibitor of cardiomyocyte apoptosis in Dexamethasone-induced hypertensive Sprague dawley rats

Linawati Hananta*, Alicia Gani, Tena Djuartina, Dion Notario

Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Refer this article

Linawati Hananta, Alicia Gani, Tena Djuartina, Dion Notario, 2024. Potential of bovine lactoferrin as an inhibitor of cardiomyocyte apoptosis in Dexamethasone-induced hypertensive Sprague dawley rats. Journal of medical pharmaceutical and allied sciences, V 13 - I 3, Pages - 6585 – 6590. Doi: https://doi.org/10.55522/jmpas.V13I3.6258.

ABSTRACT

Elevated blood pressure, also known as hypertension, significantly increases the risk of developing heart disease. It can damage heart muscle cells and trigger apoptosis (cell death). Antioxidants like lactoferrin can help protect the heart from damage by reducing the generation of reactive oxygen species (ROS), harmful molecules that can damage cells. This study aims to evaluate the efficacy of lactoferrin in alleviating apoptosis in cardiomyocytes by assessing caspase-3 levels. This study randomly assigned 32 rats into 6 groups: control, dexamethasone, positive control, and 3 lactoferrin groups (100, 300, and 500 mg/kg BW/day). All groups except control received dexamethasone for 14 days. On day 14, rats were euthanized, and heart muscle tissue was collected. Caspase-3 levels were measured and analyzed using One-Way ANOVA. The average caspase-3 enzyme levels in the lactoferrin-treated groups with 100, 300, and 500 mg/kg BW/day were 2,605.0, 2,720.9, and 2,518.8 ng/mL, respectively.

Keywords:

Apoptosis, Cardiomyocytes, Caspase-3, Hypertension, Lactoferrin

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