Exploring micro needles applications in rheumatoid arthritis: efficacy, safety, and patient benefits

Suruchi Agarwal*, Shruti Khare, Diptee Gupta

Krishna Institute of Pharmacy and Sciences, Kanpur, Uttar Pradesh, India

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Suruchi Agarwal, Shruti Khare, Diptee Gupta, 2024. Exploring micro needles applications in rheumatoid arthritis: efficacy, safety, and patient benefits. Journal of medical pharmaceutical and allied sciences, V 13 - I 6, Pages - 6829 – 6839. Doi: https://doi.org/10.55522/jmpas.V13I6.6687.

ABSTRACT

The most significant organ in the body, the skin is also where many drugs are administered. Many benefits, including averting first-pass liver metabolism, maintaining a steady levels of plasma, safety, as well as complying over oral or parenteral methods, come with drug delivery via the skin. A few of the microscale physical improvements that significantly broadens the range of medications available for through the skin and intradermal application is the use of microneedles. Microneedles are delineate to pierce the stratum corneum, the topmost layer of the skin, deprive of giving rise to considerable exertion or tissue destruction. They are consistently tens to hundreds of micrometres in size. An array of goods, for instance silicon, polymers, and stainless steel, has been utilized to create solid, coated, hollow, and dissolvable microneedles. Meanwhile, because of their superior biocompatibility, reduced preparation expense, and strong mechanical qualities, biodegradable polymers have steadily emerged as the material of choice for creating MNs. The technique of creating microneedle arrays enhances safety, effectiveness, and bioavailability to enable medication delivery via the skin. The autoimmune disease known as rheumatoid arthritis (RA) is marked by chronic synovitis, reduced joint function, inflammation, proliferation of synovial cells, formation of pannus, and consequent loss of cartilage as well as bone. In recent years, microneedles have proven to be an incredibly effective therapeutic tool in the delivery of medications, genes, proteins, RNA, and vaccinations. The many kinds of MNs, the materials utilised to make them, and their characteristics in terms of administering treatments for rheumatoid arthritis are all covered in the current review.

Keywords:

Microneedle, Transdermal, Skin, Patient compliance, Efficacy, Therapeutic effect.

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