Phytochemical composition and neuroprotective potential of Mirabilis jalapa: a review

Disha NS*, Ashok Kumar BS, Mamatha HS, Mohammed Khalid

Department of Pharmaceutical Chemistry, R. L. Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India

Refer this article

Disha NS, Ashok Kumar BS, Mamatha HS, Mohammed Khalid, 2024. Phytochemical composition and neuroprotective potential of Mirabilis jalapal: A review of its therapeutic applications in neurological disorders. Journal of medical pharmaceutical and allied sciences, V 13 I 6, Pages
6855 6870. Doi: https://doi.org/10.55522/jmpas.V13I6.6727.

ABSTRACT

Four-o’clock plant, scientifically named as Mirabilis jalapa, has gained significant attention for both its ornamental beauty and its medicinal properties, widely utilized as folk remedies. It is a plant grown in the warm climate as a species and showed different pharmacological effects in various therapeutic sectors such as neuroprotective and anxiolytic. Using PubMed, Web of Science Semantic Scholar and Google Scholar and the search terms Mirabilis jalapa phytochemicals; neuroprotection; anxiolytic effect; traditional medicine; flavonoids; alkaloids and neurological disorders literature supporting the medicinal role of Mirabilis jalapa were sourced. The members of Mirabilis jalapa contain flavonoids, alkaloids, triterpenes leaves and saponin through which it provides possibility for the neuroprotection feature. According to research, extracts of the plant can help prevent oxidative stress, a major factor in illnesses including Alzheimer’s and Parkinson’s. Animal studies reveal that components from M. jalapa interfere with Aluminum cytotoxicity by increasing antioxidant enzyme levels, as well as decreasing oxidative damage biomolecules. In addition, the flavonoid constituent has anxiolytic effects because its extract interferes with GABAergic transmission, whereas its effectiveness is comparable to diazepam. Furthermore, the plant has exhibited anticonvulsant effect possibly due to interaction with Ca channel and Glu transmission. Thus, these studies show directions in which the plant works, indicating that it may possess valuable means to treating neurological disorders. However, further clinical trials are needed to understand the exact effects of the plant in human organisms. Mirabilis jalapa therefore, is Discovered to be of great potential as a natural antioxidant and neuroprotective compound as well as anxiolytic remedies.

Keywords:

Mirabilis jalapa, phytochemicals, neuroprotection, anxiolytic, traditional medicine, flavonoids, alkaloids, therapeutic potential, neurological.

Full Text Article