An observational study on incidence of acute pancreatitis in different age groups and associated risk factors

Parash Niroula, Sri Lakshmi Sanipini, Prince Kumar Yadav, Rutendo Moleen Mautsa, Rakurthi Sai Vijay Kumar, Penugonda Vineela*

Department of Pharmacy Practice, Aditya College of Pharmacy, Surampalem, Andhra Pradesh, India

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Parash Niroula, Sri Lakshmi Sanipini, Prince Kumar Yadav, Rutendo Moleen Mautsa, Rakurthi Sai Vijay Kumar, Penugonda Vineela, 2025. An observational study on incidence of acute pancreatitis in different age groups and associated risk factors. Journal of medical pharmaceutical and allied sciences, V 14 - I 1, Pages - 6936 – 6944. Doi: https://doi.org/10.55522/jmpas.V14I1.6795.

ABSTRACT

About 275,000 occurrences of acute pancreatitis (AP), an inflammatory disease of the pancreas, were recorded in the US in 2009. AP frequently results in hospitalization. It has a 1-5% mortality rate and can be caused by a variety of factors, with gallstones and excessive alcohol usage accounting for 70–80% of cases. Pancreatic hyperstimulation and bile duct obstruction are the causes of biliary pancreatitis, which is more frequent in women. Both chronic and acute pancreatitis are made more likely by alcohol use, with long-term alcohol use making the pancreas more sensitive to other variables such as smoking or high-fat diets. Significant risk factors include obesity and hypertriglyceridemia; around 10% of instances of acute pancreatitis are caused by elevated triglyceride levels, which may harm pancreatic cells. Post-procedure pancreatitis can also result from endoscopic procedures such as endoscopic retrograde cholangiopancreatography (ERCP). Despite being uncommon, drug-induced pancreatitis affects 0.1–2% of people and has a significant fatality rate, particularly in severe cases. This illness is frequently underreported and underdiagnosed, especially in older adults who take several drugs. Understanding of the biological processes behind pancreatitis, especially the activation of digestive enzymes, has improved due to recent developments in molecular biology. The illness is still complicated, though, and a number of risk factors influence its onset and course.

Keywords:

Acetazolamide, Congestive heart failure (CHF), Comorbidities, Cardiac function, MLHFQ Questionnaire.

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