Co-crystal formation of cilnidipine with urea and benzoic acid: an efficient approach to enhance the solubility and dissolution rate

Punita Yadav, Manoj Kumar Mishra*, Shekhar Gautam Singh, Atul Kumar Sahu, Keshwar Raj Prasad

Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Allahabad, Uttar Pradesh, India

Refer this article

Punita Yadav, Manoj Kumar Mishra*, Shekhar Gautam Singh, Atul Kumar Sahu, Keshwar Raj Prasad, 2016. Co-crystal formation of cilnidipine with urea and benzoic acid: an efficient approach to enhance the solubility and dissolution rate. Journal of medical pharmaceutical and allied sciences, V 5 - I 1, Pages -286 – 289. Doi: https://doi.org/10.55522/jmpas.V5I1.0075.

ABSTRACT

Co-crystallization is the process to enhance the physical properties of the molecule, especially the solubility and dissolution rate. The physical and chemical property improvements through pharmaceutical co-crystals draw closer the fields of crystal engineering and pharmaceutical science. Objective:In this work BCS Class II drug Cilnidipine is used as a model drug, which is having poor solubility but high permeability is incorporated with urea to enhance bioavailability and dissolution rate. Co-crystals are formed by solvent evaporation and solvent drop grinding method with urea and benzoic acid as a co-formers. Methanol is used as a solvent. Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD) and FTIR techniques were employed to support the formation of co-crystals and to find out the optimized ratio of components of co-crystals. All the prepared co-crystals showed high solubility to the parent drug. Based on the formulation development and their results, co- crystals engineering is viable alternative to increase the aqueous solubility of poorly soluble drugs, which ultimately increases dissolution profile and bioavailability.

Keywords:

Co-crystallization, Cilnidipine, Urea, Benzoic Acid, Methanol.

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