TECHNIQUES FOR SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS: AN OVERVIEW

Sikarra Deepshikha *, Shukla Vaibhav, Kharia Ankit Anand, Chatterjee D. P.

Vaibhav Shukla, Oriental College of Pharmacy, Bhopal

ABSTRACT

A success of formulation depends on how efficiently it makes the drug available at the site of action. Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for drugs. This is true for parenterally, topically and orally administered solutions. Hence various techniques are used for the improvement of the solubility of poorly water soluble drugs include hydrotrophy, use of salt form, use of precipitation inhibitors, alteration of pH of the drug micro-environment, solvent deposition, precipitation pH adjustment, co-solvency, micellar solubilization, super critical fluid techniques, solid dispersion, complexation, micro-emulsion, solid solution, eutectic mixture, selective adsorption on insoluble carriers, evaporative precipitation into aqueous solution, use of surfactants, use of amorphous, anhydrates, solvates and nanonisation.

Keywords: Solubility, solubility enhancement, nanonisation, poorly water soluble