Stability Indicating Validated Spectrometric Method for Simultaneous Estimation of Citalopram & Clonazepam in Marketed Formulation

Amita Patel*, Manisha Shrivastava, Ruchi Omre, A K Jain, Aditya Mishra

Department of Quality assurance, Sager Institute of Pharmaceutical Sciences, Saugar, Madhya Pradesh, India

Refer this article

Amita Patel, Manisha Shrivastava, Ruchi Omre, A K Jain, Aditya Mishra, 2012. Stability indicating validated spectrometric method for simultaneous estimation of citalopram & clonazepam in marketed formulation. Journal of medical pharmaceutical and allied sciences, V 1 - I 1, Pages -19 – 24. Doi: https://doi.org/10.55522/jmpas.V1I1.0004.

ABSTRACT

Simple, sensitive, specific and economic spectrophotometric method was developed and validated for simultaneous quantitation of Citalopram & Clonazepam in tablet dosage form. New method based on the simultaneous estimation of drugs in a binary mixture without previous separation was developed. In simultaneous equation method, Citalopram & Clonazepam were quantified using their absorptivity values of at selected wavelengths, viz., 239 nm and 308 nm respectively. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The simultaneous equation method permits simple, rapid and direct determination of Citalopram & Clonazepam in commercially available tablet dosage form without previous separations and can therefore be used for routine analysis of both drugs in quality control laboratories.

Keywords:

Citalopram, Clonazepam, Validation Vierodt’s method

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