Hepatoprotective activity of powdered leaves extract of Adenanthera Pavinia against Paracetamol induced liver damage in rats

Aleem M.*1, Sagar Rakesh1, Sahu Himanshu Bhusan1

ABSTRACT

The extract of plant Adenanthera Pavinia was studied for hepatoprotective activity against Swiss albino rats with liver damage induced by Paracetamol. It was found that the different extract of Adenanthera Pavinia at a dose of 500 mg/kg body weight exhibited moderate protective effect by lowering the serum levels of alanine aminotransferase(ALT) or Serum Glutamate Pyruvate Transaminase (SGPT), aspartate aminotransferase (AST)or Serum Glutamate and Oxaloacetate Transaminase (SGOT) to a significant extent. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical studies of blood samples of Paracetamol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by Paracetamol and blood samples from the animals treated with the extracts of Adenanthera Pavinia showed significant decrease in the level of serum markers, indicating the protection of hepatic cells, the extract of above plant could afford significant dose-dependent protection against paracetamol induced hepatocellular injury.

Keywords: Hepatotoxicity, Paracetamol, OECD, Adenanthera Pavinia