FORMULATION AND OPTIMIZATION OF MOUTH DISSOLVING TABLET OF BACLOFEN BY DIRECT COMPRESSION METHOD USING TWO DIFFERENT SUPERDISINTIGRANTS

ABSTRACT

Mouth dissolving tablets facilitates in resolving swallowing issues of oral dosage forms. Baclofen was selected as a model drug. Reverse concentration of croscarmellose sodium and cross povidone were used as superdisintigrants in concentration of 40% of total tablet weight with appropriate concentration of other excipients. Prepared batches of tablets were evaluated for hardness, friability, content uniformity, wetting time, Water absorption ratio, disintegration time, dissolution studies and stability studies. The optimization is based on immediate disintegration time (approximately 25-35 seconds) and in-vitro drug release pattern. Disintegration time and invitro drug release were tested in 0.01N Hcl solution occur relevant drug release pattern. The formulation F5 and F3 contained 40% w/w. Crospovidone emerged as an impending polymer (95% release and total DT is 1.31 minutes) based on drug release characteristic (in 0.01N Hcl solution) compared to controlled formulation.

Keywords: Baclofen, superdisintigrants, therapeutic effectiveness, optimization, direct compression