EXPERIMENTAL INTERVENTION TO PREVENT FLUORIDE EXPOSURE

ABSTRACT

This study is attempted to develop a preventive measure against fluoride exposure in the endemic areas of India and other countries. This Experimental approach involves prevention of fluorosis with Calcium lactate and Ascorbic acid. The water samples were collected from endemic areas of Nalgonda district and its fluoride levels were estimated; and considered as fluoride control. The animal study on prevention of fluorosis was performed on 24 Wister albino rats which were divided into four groups. It was found that calcium lactate and ascorbic acid binds to fluoride ions in the GIT and forms an insoluble complex which significantly (P<0.001) decreases the fluoride absorption. It shows that diet supplemented with high calcium dose and ascorbic acid are significantly effective (P<0.001) in therapies of fluorosis.Calcium lactate and Ascorbic acid has shown potential in prevention of fluorosis. It can be a promising therapy against fluorosis.

Keywords: Fluorosis, skeletal fluorosis, Pre-clinical, Water.