FORMULATION AND EVALUATION OF IN -SITU OCULAR DRUG DELIVERY SYSTEM OF GENTAMICIN SULPHATE

ABSTRACT

Stem paste of Terminalia cardifolia commonly known as Guduchi (‘Giloya' in India) was found to be useful in the management of eczema. In ayurveda, giloy is used to treat acute infections and as a digestive aid, aphrodisiac and diuretic. Since the mechanism of action of is not known, we aimed to investigate the actions of Giloya on mast cell activation. Effects of aqueous extracts of Giloya on mediator release from rat peritoneal mast cells (RPMCs) and cytokine production from HMC-1 were investigated. Aqueous extract of Giloya significantly attenuated histamine release and prostaglandin D 2 synthesis from RPMC activated by anti-IgE and compound 48/80 (p < 0.05). However, these herbs failed to affect cytokine production in HMC-1. Inhibition of inflammatory mediator release from mast cells will contribute to the therapeutic efficacy of Giloya.

Keywords: Giloya, Ayurvedic medicine, PGD2, animal sensitization, Mast cells.