MICRONEEDLE: AN EMERGING TECHNOLOGY FOR PAIN FREE DELIVERY

Pitliya Prateek 1*, Saini Pramod 1, Pareek Ajay Kumar 1, Garg Shiv 1, Choudhary Kavita 2, Nitin Nama3

Dept. of Pharmaceutics, Maharishi Arvind College of Pharmacy, Ambabari, Jaipur, Rajasthan, INDIA

ABSTRACT

This review presents advancement in the field of Micro system Technology and specifically in the area of microneedle-based drug delivery. The objective of this review is to highlight the potential role of microneedles in achieving painless drug delivery of macromolecular drugs across the skin barrier. The dosing in microgram quantities can be done by this type of needle.The stratum corneum is the main barrier for transdermal drug transport. It could be bypassed by microneedles, which have a length of a few tens to a few hundreds of microns. They are usually arranged in arrays and can be used in several ways to enhance transdermal drug transport. Hollow needles of micron dimensions have previously been fabricated and envisioned for use with transdermal patches or infusion pumps to achieve painless delivery of drugs to the skin for local and systemic effects without the need for hypodermic needles. However, little work has been carried out to identify methods to effectively use hollow microneedles for drug delivery. The various method of preparation of microneedles include molding, casting, laser cutting. The in-vivo safety assessment and the evaluation of microneedle have shown that this technique can be used safely.

Keywords: Microneedle, Transdermal drug delivery, Microsystem Technology (MST), DNA vaccine delivery, Nanoject, Photodynamic therapy