Intranasal administration: A potential route for targeting CNS

Singh Joga^1*, Singh Birjatinder², Malik Vivek Singh³

Department of phramaceutics, G.G.N. Khalsa college of pharmacy, Ludhiana, Panjab, India, 141001

ABSTRACT

Depression, the common psychological disorder, affects about 121 million people worldwide. It is common psychological disorder, characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness and poor concentration. A key obstacle for developing effective drugs and treatment regimens for treating neurological disease is blockage of drug entrance into the Central Nervous System by the Blood Brain Barrier. Depressive symptoms like feelings of hopelessness, suicidal tendencies, irritability, insomnia or hypersomnia etc. may compel the patients not to take medicines orally. So intranasal delivery of antidepressant drug can be a solution, intranasal drug delivery is now recognized to be a potential route for delivery of drugs directly into the CNS. The nasal route provides an attractive needle-free alternative for currently injectable drugs which may improve patient compliance and allow extended use of self-medication for many chronic diseases / acute conditions.

Keywords: Depression, Drug, Central Nervous System, Intranasal