Co-Crystal Formation Of Cilnidipine With Urea And Benzoic Acid: An Efficient Approach To Enhance The Solubilty And Dissolution Rate.

Yadav Punita, Mishra Manoj Kumar, Gautam Singh Shekhar, SahuAtulKumar, Prasad Raj Keshwar

Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Allahabad, Uttar Pradesh, India-211012Correspondence

ABSTRACT

Background:Co-crystallization is the process to enhance the physical properties of the molecule, especially the solubility and dissolution rate. The physical and chemical property improvements through pharmaceutical co-crystals draw closer the fields of crystal engineering and pharmaceutical science. Objective:In this work BCS Class II drug Cilnidipine is used as a model drug, which is having poor solubility but high permeability is incorporated with urea to enhance bioavailability and dissolution rate.Methods:Co-crystals are formed by solvent evaporation and solvent drop grinding method with urea and benzoic acid as a co-formers. Methanol is used as a solvent.Result:Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD) and FTIR techniques were employed to support the formation of co-crystals and to find out the optimized ratio of components of co-crystals.Conclusion: All the prepared co-crystals showed high solubility to the parent drug. Based on the formulation development and their results, co-crystals engineering is viable alternative to increase the aqueous solubility of poorly soluble drugs, which ultimately increases dissolution profile and bioavailability

Keywords: Co-crystallization, Cilnidipine, Urea, Benzoic Acid, Methanol