DOI:
VOLUME-5, ISSUE-9
AKASH CHANDRAKANT NANDANIKAR
Department of pharmaceutics Appasaheb Birnale College of pharmacy, Sangli. Maharashtra, India. 416416
ABSTRACT
Chewable tablets which are required to be broken and chewed in between the teeth before ingestion. These tablets are given to the children who have difficulty in swallowing and to the adults who dislike swallowing. These tablets are intended to disintegrate smoothly in the mouth at a moderate rate either with or without actual chewing, characteristically chewable tablets have a smooth texture upon disintegration, are pleasant tasting and leave no bitter or unpleasant taste. Geriatric and pediatric patients and travelling patients who may not have ready access to water are most need of easy swallowing dosage forms like chewable tablets. The drug release of intact Diclofenac Potassium was found to be 98.09% the drug release was purely depend on the factor [b1] that was Crosscarmellose sodium. It indicates that increasing the concentration of Crosscarmellose sodium lads to increase in the drug release and increase in concentration of mannitol leads to decrease in the drug release. As the factor [b1] shows the positive number, which indicates that the Crosscarmellose Sodium has a positive impact on the drug release. And the factor [a1] showed the negative effect, which was mannitol. The relationship between variables that is [a1] Mannitol and [b2] Crosscarmellose sodium was further elucidated by using the response plot. The percentage release of intact Sucralfate tablet showed all values within limits, in which the [a1] showed the negative effect on the drug release and [b1] which is Crosscarmellose sodium shows the positive effect on the drug release. The coefficient value of [a1] was found to be less than that of [b1], which indicates that Crosscarmellose sodium has more effect of drug release than mannitol. The drug release of Sucralfate was found to be 97.02%, in which the [a1] was of mannitol, which indicates that it had a negative effect on drug release, and [a2] indicates that it had a good positive effect on the drug release.We can see that as the concentration of mannitol was increased, there was decrease in the dissolution seen, from which it was concluded that the mannitol had a negative effect on the drug release, and which was denoted by a (-) sign in the equation.The data clearly indicates that the drug release of crushed diclofenac potassium was dependent on the concentration of both mannitol and crosscarmellose sodium. .The coefficient [a1] and [b1] were found to be significant to the predicted release below 20min.The disintegration of all the tablets showed the disintegration time up to 5 min 40 sec, in which there were two polymers in which a [1] showed the negative effect, which was mannitol, and b [1] showed the positive effect, which means that Crosscarmellose sodium had a positive effect on the disintegration of tablets. As the concentration of mannitol increases the disintegration time. As its clearly seen that as the concentration of crosscarmellose sodium is increased there is increase in the disintegration time as per expectation, but as the concentration of mannitol was increased there was effect seen on the tablet disintegration.
Keywords: chewable tablet, gum core, antioxidant, compressibility etc.