IMPLICATION OF HEAT SHOCK PROTEINS IN PERIODONTAL DISEASE

Dr. Ashank Mishra

Associate Professor, Department of Periodontics, Sri Sai
College of Dental Surgery, Vikarabad.

ABSTRACT

Heat shock proteins are found in virtually all living organisms, from bacteria to humans. Theystabilize proteins and are involved in the folding of denatured proteins.During the infection, HSP from several bacterial species are recognized by host as immunodominant antigens. Periodontopathic bacteria have sequence homology with human HSP 60 at amino acid level, which raises the possibility of cross reactivity. The present review gives an insight into the role of HSPs in the etiopathogenesis of periodontal disease.

Keywords: Heat shock proteins, Periodontopathic bacteria, cross reactivity.