FORMULATION AND EVALUATION OF LANSOPRAZOLE FAST DISSOLVING TABLETS

RAVELA NAVYA DURGA, 

Department of Pharmaceutics, V.L.College of Pharmacy,
Raichur, Karnataka

ABSTRACT

Background: Fast dissolving tablets are those when put on tongue disintegrate/dissolve/disperse instantaneously releasing the drug which dissolve or disperses in the saliva with Their characteristic advantages such as administration without water, anywhere, anytime lead to their suitability to geriatric and paediatric patients. Objective: lansoprazole is prescribed to elderly patients whose swallow function is reduced with high frequency. Therefore, a new lansoprazole preparation that is useful for swallow function deficient patients is needed. Keeping an objective an attempt is made to develop fast dissolving tablets of lansoprazole. Methods: Fast dissolving tablets of lansoprazole were prepared using natural super disintegrating agents viz., pregelatinized starch and treated agar at different concentrations. The prepared fast dissolving tablets evaluated for pre compression and post compression parameters studies to check the compatibility of drug and excipients and properties of tablets. Optimized fast dissolving tablets were compared with controlled and marketed tablets. Results: FTIR and DSC studies suggest there is no interaction between drug and the superdisintegrants. Precompression studies and post compression studies suggest that the values were found to be within the limits and are in accordance with pharmacopoeial standards. The wetting time, dispersion time and disintegration time were directly proportional to the concentration of super disintegrants. Conclusions: The results of in vitro dissolution studies suggest a direct relationship of concentration of super disintegrants with drug release irrespective diluents used in the studies. As the amount of superdisintegrant increases the drug release also increases.

Keywords: Lansoprazole, Pregelatinized starch, Treated agar, Fast dissolving tablets