Shabana Sultana, M.A.Doshi, N.Jayasree, Mrudula Chandrupatla

DOI:

VOLUME-5, ISSUE-12

Effect of sodium valproate in histological features of cerebellum in chick embryos

Shabana Sultana, M.A.Doshi, N.Jayasree, Mrudula Chandrupatla

1. Tutor, Department of Anatomy, Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India.

2. Professor and Head, Department of Anatomy, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

3. Dean and Professor, Department of Anatomy, Sakshi Medical College and Research Centre, Myana, Guna, M.P., India.

4. Professor and Head, Department of Anatomy, Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India.

ABSTRACT

Valproic acid is an antiepileptic drug prescribed as monotherapy in newly diagnosed cases of Epilepsy. It is also useful in combating generalized Tonic-Clonic Seizures, Partial Seizures, Myoclonic Seizures. It acts by increasing the levels of the Neurotransmitter GABA in the cerebrum. Valproate inhibits sustained repetitive firing induced by depolarization of cortical or spinal cord neurons . It produces small reductions of the low-threshold(T) Calcium current at clinically relevant but slightly higher concentrations then limit sustained repetitive firing. Reducing T currents may contribute to the effectiveness of Valproic acid against partial and tonic–clonic seizures and absence seizures respectively. In vitro,Valproate can stimulate the activity of the GABA synthetic enzyme,Glutamic Acid Decarboxylase and inhibit GABA degradative enzymes,GABA trasaminases . But studies show that they cause defects in the formation of neural tube if used during pregnancy. In the present study fertilized eggs were administered with Sodium Valproate at 24 hours of incubation and the development of Cerebellum was studied after 20 days. The histological and gross features of Cerebellum were identified.

Keywords: Sodium Valproate, Chick Embryo, Cerebellum

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