FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF PROCHLORPARAZINE DIMALIATE

Dr. Rathi Jagdish, Sahu Rahul Kumar*, Solanki Praveen, Kotwar Ramesh, Khan Nadeem, , Mathur Rahul

NRI institute of pharmaceutical sciences, Bhopal, India

ABSTRACT

A oral fast dissolving film is a type of multiple new drug delivery system. aim and objective to prepare and evaluate fast Dissolving oral film of Prochlorperazine to reduce the pain like migraine with fast relief. Prochlorperazine oral film quickly disintegrates and dissolves, and can be administered without water, making them particularly suitable for geriatric patients and found faster action. The immediate release layer containing PEG600, HPMC, EC, Citric acid was prepared by solvent casting method and fast release layer containing HPMC, EC, Citric acid (in desired concentrations) was. The drug content of film revealed that the drug was uniformly mixed in the polymers. In-vitro dissolution studies revealed that formulation has showed the initial release of immediate release layer dose. The kinetic data showed that drug release from film follow Zero order, Higuchi plot indicated that the formulation follow Diffusion controlled release mechanism.

Keywords: orodispersible, polymeric film, , mucoadhesive, quick release, antipsychotic