Abdel Karim. M., Abdelwahab A., Sayed,E., Mahmoud,I.N.

DOI:

VOLUME-5, ISSUE-12

Isolation and Characterization of a Flavone From Acacia orfota (Forssk.) Schweinf and Biological Activity of Total Extract

Abdel Karim. M., Abdelwahab A., Sayed,E., Mahmoud,I.N.

1-Sudan University of Science and Technology, Faculty of Science, Dept. of Chemistry

2- University of Zalingei , Sudan

3- National Research Centre, Dept. of Tannins Chemistry , Dokki,Cairo,12622,Egypt

4-Department of Natural Compounds Chemistry, National Research Centre (ID: 60014618), Dokki, 12311, Cairo, Egypt.

ABSTRACT

Information on the constituents of medicinal plants used in Sudanese ethnomedicine is very scarce. Hence, this study was set to investigate the phenolics of the medicinally important species Acacia orfota which is widely used in ethnomedicine to treat a wide array of human disorders. A Flavone was isolated from the leaves and its structure was partially elucidated on the basis of its spectral data(UV,1HNMR and MS). Antimicrobial activity of the total extract was screened in vitro against a panel of Gram positive and Gram negative bacterial pathogens and fungi, in comparison with control drugs and significant results were obtained.

Keywords: Acacia orfota , Isolation , Flavone, Antimicrobial Activity.

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