Mean platelet volume and neutrophil to lymphocyte ratio in Behçet’s Disease

Betul Sereflican, BenguTuman

1. MD, Assistant Professor, Department of Dermatology, Medical Faculty, AbantIzzetBaysal University, Bolu, Turkey 

ABSTRACT

Introduction: Behçet’s Disease (BD) is a systemic inflammatory disease. Mean platelet volume (MPV) is a marker of platelet function and the neutrophil to lymphocyte ratio (NLR) is an indicator of inflammation. We investigated the levels of MPV and NLR in patients with BD and healthy individuals.We purposed to investigate the association of NLR and MPV with BD and disease activity. Methods: Twenty-eight patients diagnosed with BD and 28 healthy subjects were enrolled in this study.Blood samples of patients and controls were measured for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and full blood counts for white blood cells (WBC), MPV and NLR. Results: The MPV levels in patients with BD were significantly higher than controls (p=0.002). The difference in NLR values between patient and control group was not significant (p=0.068). No significant difference was found in the NLR values between the patients with and without active lesions (p = 0.175). Also there was no significant difference in the MPV values between the patients with and without active lesions (p=0.35).There was no correlation between disease duration, disease severity and MPV and NLR values. Conclusion: The MPV levels may be used as an inexpensive and practical diagnostic marker in patients with BD.

Keywords: Behçet’s Disease, mean platelet volume, neutrophil to lymphocyte ratio