DESIGN AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ZIDOVUDINE HYDROCHLORIDE: COMBINATION OF NATURAL POLYMERS

Harekrishna Roy, Bhabani Shankar Nayak

1. Research Scholar, Biju Patnaik University of Technology, Rourkela, Odisha, India
2. Department of Pharmaceutics, Nirmala College of Pharmacy, Atmakur, Guntur, AP, India.
3. Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Koraput, Odisha, India

ABSTRACT

The current paper was a shot to style a sustained unharness dosage kind victimisation varied grades of hydrophilic polymers, Hypromellose or Hydroxy- propyl alkyl radical polysaccharide (HPMC K15M, HPMC K100M), Sodium alginate and Chitosan additionally incorporated as rate retarding. Material Methods: Laboratory scale batches of six tablet formulations were ready by wet granulation technique (Low shear). Micromeritic properties of the granules were evaluated before compression. Tablets were characterised as crushing strength, friability, weight variation, thickness, Drug content or assay and evaluated for in-vitro unharness pattern for fifteen unit of time victimisation Phosphate buffer of suitable pH 6.8 at 37±0.5°C. Results and discussion: The results obtained discovered that HPMC K15M, Chitosan , Sodium alginate and Ethylcellulose at an acceptable concentration formulation (F4) was able to sustain the drug unharness for fifteen hours and followed Higuchi pattern similar Fickian diffusion. It had been found that every one parameters were at intervals the limit of acceptance. There was slight chemical interaction found between the drug and excipients throughout FT-IR and DSC study thought of in the present investigation. Conclusion: therefore it may be over that combinely polymers at an acceptable concentration will effectively be formulate to sustain the drug unharness.

Keywords: Zidovudine, Chitosan, Sodium alginate, Higuchi, Validation, Drug content