PENTOXIFYLLINE: APPLICATIONS IN DENTISTRY

Dr. Pratik C. Parkarwar1, Dr. Afroz Anjum2, Dr. Nilofar Zaidi3, Dr. Saudagar Mohd.Ziauddin4, Dr. Lata Kale5, Dr. Sagar Khairnar6, Dr. Pravin Gaikwad7, Dr. Rajendra Birangane8, Dr. Mona Shah9, Dr. Yogesh Doshi Reader10, Dr. Prashant Kore11

ABSTRACT

Pentoxifylline is a methylxanthine imitative with a range of anti-inflammatory effects presently pentoxifylline is permitted by the Food and Drug Administration for the management of intermittent claudication, but studies have revealed that it has a diversity of physiological effects at the cellular level which may be significant in treating a different group of diseases. Clinical 646 Journal of Medical Pharmaceutical and Allied Sciences (March_2017); 645-654 applications of pentoxifylline in dentistry have been reviewed Effects of PTX on different cellules and molecules Anti-TNF-α effects ,tumor Necrosis Factor-α is a cytokine with a wide spectrum of activity which is predominantly produced by mononuclear cells. Increasing evidence has implicated TNF-α as a pivotal molecule involved in the pathogenensis of a wide variety of acute and chronic inflammatory disease states including many skin diseases such as psoriasis, graft-versus-host-disease (GVHD), contact dermatitis , leprosy reactions, OSMF, AIDS.

Keywords: Pentoxifylline, TNF, GVHD, AIDS, OSMF.