SOY AND ITS ISOFLAVONES ANALYSED AS PREVENTIVE AND THERAPEUTIC EFFECT ON B16F10 TUMOR MODEL

Sharma Pratima, Uma Devi P, Thakur Indu*

Jawaharlal Nehru Cancer Hospital and Research Centre Idgah hills Bhopal, India.

ABSTRACT

Study the therapeutic and preventive effects of soybean and its Isoflavones on B16F10 melanoma tumor in mice. Among various oral treatments, results indicated maximum regression in tumor formation in terms of the volume doubling time and growth delay for the therapeutic as well as preventive treatments. The difference for both the parameters were significantly high with (P<0.001) as compared to the control. The response of silent period for preventive effect was also highly significant (P<0.001). The long-term survival studies demonstrate that the mean survival time of animals kept on diet. Supplemented with full fat soy flour (FFSF) and Isoflavones was observed to be 39.25 days and 41.5 days respectively as against control (30.76days). The respective % increases in life span of mice were 33.33% and 41.37%. The result on the therapeutic effect of FFSF and isoflavones indicated the MST of 40 days and 44.9 days respectively as compared to control (28.2days while the respective % ILS was 41.38 days and 58.89 days. As against 29.2 days of MST for control group in case preventive effect, the MST of 38.33 days and 55.33 days. Both the group i.e. therapeutic and preventive, exhibited highly significant increase in the MST (P<0.005) as well as % ILS compared to control. It may be emphasized that more than 25% increase in life span of cancer patient is considered as effective antitumor response.

Keywords:

FFSF (Full fat Soy Flour), Isoflavones, Volume doubling time, Increase Life span (ILS)