The Effect of hydroalcoholic chicorium Extract on QT Interval of Heart and its Histopathology in Biliary Cirrhosis Induced by Bile Duct Ligation in Rats

Mahin Dianat, Mohammad Badavi, Reihaneh Jelodar

Committee of Ahwaz
Jundishapur University of
Medical Sciences, Ahwaz, Iran

ABSTRACT

QT prolongation is a problem that increases the ventricular arrhythmias in the cirrhotic patients. Chicorium extract has been reported to have potential anti-inflammatory and antioxidant activity.This study aimed to find the effect of chicorium extract on QT interval of heart and its histopathological parameters in rats with biliary cirrhosis induced by bile duct ligation (BDL).Thirty two male Sprague Dawley rats (200 - 250 g) were divided into 4 groups; negative control,cirrhotic, and 2 cirrhotic groups treated with chicorium extract in doses of 50 mg/kg and 100 mg/kg orally for 4 weeks. In all groups before BDL and 4 weeks after surgery animals were anesthetized and their electrocardiograms were recorded. After the required period of BDL, liver was isolated and immersed in 10% formalin solution and stained by hematoxylin and eosin for histological studies. Student t-test and one-way ANOVA. P < 0.05 was considered as significant level. The QT interval was calculated using the Bazett's formula and corrected QT (QTc) was obtained. Histopathological parameters were reduced in cirrhotic groups treated with extract compared to control cirrhotic group. These results revealed that cirrhosis produce prolonged QT interval and chicorium extract has an ameliorating effect on QT prolongation probably via its antiarrhythmic property.

Keywords:

Chicory, Cirrhosis, QT
Interval, Histopathology,
preclinical study