ANTIMICROBIAL ACTIVITY OF LEAF OF SPHAERANTHUS INDICUS AGAINST SOME SELECTED HUMAN PATHOGENIC BACTERIA

Dhanapal Venkatachalam*, Samuel Thavamani B, Muddukrishniah K

Department of Pharmacognosy, Sanjo College of Pharmaceutical Studies, Velappara, Palakkad, Kerala, India

ABSTRACT

The evolution and spread of antibiotic resistance, as well as the evolution of new strains of disease causing agents, is of great concern to the global health community. Our ability to effectively treat disease is dependent on the development of new pharmaceuticals, and one potential source of novel drugs is traditional medicine. This study explores the antibacterial activity of aqueous, Methanolic extracts and oil of Sphaeranthus indicus against different species of bacteria like Staphylococcus aureus, Streptococcus faecalis, and Escheriachia coli. Anti-bacterial activity of S.indicus extract was measured by Filter paper disc method. Aqueous extract of S.indicus leaf showed the largest zone of inhibition (25mm) against S. faecalis and 22 mm zone of inhibition against S.aureus. The present study demonstrates that the leaves of S.indicus are potentially good sources of antibacterial against the pathogens (Staphylococcus aureus, Streptococcus faecalis). They could be used as alternatives to common anti-microbial agents for treatment of bacterial infections. Clinical Pharmacist should inform the clinicians about these adverse reactions during each administration time. In India, Pharm D graduates are trained to become Clinical Pharmacist in hospital.

Keywords:

Anti-bacterial activity, Sphaerantus indicus, Staphylococcus aureus, Streptococcus faecalis. Escheriachia coli Agents.