ALLOPOLYHERBO TABLET FORMULATION AND EVALUATION FOR MIGRAINES FROM DIRECT COMPRESSION METHOD

Sonawane Harshali R*, Dr. Surana Santosh S, Dr. Maru Avish D

Dr. J. D. Pawar College of pharmacy Manur, Nashik, Maharastra, India

ABSTRACT

The formulation research towards the safety and reduce the side effects of a containing Sumatriptan succinate, ginger and black pepper were prepared by direct compression method. Both Sumatriptan succinate and ginger used as an anti-migraine agent. Ginger prevent the side effects of Sumatriptan as well as it act as binding and disintegrating agent into tablet formulation. Black pepper improve the bioavailability and shows the bio enhancing property of Sumatriptan succinate in the formulation. The Allopolyherbo tablet evaluating by various tests weight variation, friability, hardness as per standards and also perform the disintegration test, and dissolution studies. This study results that the allopolyherbo tablet is better results than conventional tablet.

Keywords:

Anti-migraine activity, Ginger, Black pepper, Sumatriptan succinate