ACUTE ORAL TOXICITY AND ANTI TUSSIVE EFFECT OF KASHLOFF SYRUP (POLY HERBAL FORMULATION) ON SO2 INDUCED COUGH MODEL

Nilesh Patel, Dr. Janmejay Patel, Achal Patel, Dr. Upendra U. Zala*

J. S. Ayurved, Mahavidyalaya, Nadiad, Gujarat, India

Refer this article

Nilesh Patel, Janmejay Patel, Achal Patel, Upendra U Zala, 2019. Acute oral toxicity and anti tussive effect of kashloff syrup (poly herbal formulation) on so2 induced cough model. Journal of medical pharmaceutical and allied sciences, V 8 - I 5, Pages - 2333 – 2337. Doi: https://doi.org/10.55522/jmpas.V8I5.850.

ABSTRACT

The herbal drugs mentioned in classics for treatment of airway infections are better than modern drugs like anti-tussive, expectorants, mucolytic, as they have no any side effect. To evaluate acute oral toxicity on Swiss albino mice and anti tussive effect in So2 induced cough model of kashloff Syrup (Anti-tussive poly-herbal formulation). The present study was conducted according to OECD guideline AOT-425 to know single dose toxicity of Kashloff Syrup on Swiss albino mice. IAEC No. for the study is SKPCPER/IAEC/2016-02/02. The study was conducted using 5 Swiss albino mice. The male and female animals were selected for study of 8 - 12 weeks old with weight range of within ± 20 % of mean body weight at the time of randomization. A limit dose of 2000 mg/kg of extract was used involving five mice. Each mouse was treated with a single oral dose of 2000 mg/kg of extract in sequence at 48 h intervals. There were no physical and behavioral changes observed in Swiss albino mice during 14 days. Body weight of all animals did not reveal any significant change as compared to vehicle control group. So No-Observed-Adverse-Effect-Level (NOAEL) of Kashloff Syrup is 2000 mg/kg. The significant decrease in cough bouts proves potential anti tussive activity of Kashloff Syrup.

Keywords:

Anti-tussive, Poly-herbal formulation, Acute oral toxicity, Kashloff Syrup, Mortality, Swiss Albino Mice.

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