STUDY OF ANTIHYPERLIPIDEMIC EFFECT OF HYDROALCOHOLIC EXTRACT OF SOLANUM VIRGINIANUM WHOLE PLANT IN HIGH FAT DIET FED RATS

Suraj Sahu*, Narendra Patel, Hemant Kumar Sharma, Prabhakar Budholiya, Prabhat Kumar Jain

Sri Satya Sai University of Technology and medical Science, Sehore, Madhya Pradesh, India.

ABSTRACT

Elevated serum cholesterol levels leading to atherosclerosis can cause coronary heart disease (CHD).Hyperlipidemia is a major risk factor for the development of coronary heart disease and is the most common cause of mortality and morbidity worldwide. Currently available synthetic drug of hyperlipidemia are associated with a number of side effects. In recent times, a large volume of work aimed at the efficacy of herbal products, as they are safe and effective alternatives to synthetic drugs. The aim of the present study is to investigate the phytochemical profile and anti-hyperlipidemic activity of whole plant of hydro alcoholic extract Solanum virginianum in high-fat diet induced hyperlipidemic rats at a dose of 100 and 200mg/kg. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolic and flavonoids were determined by the well-known test protocol available in the literature. The activity was assessed by estimation of serum lipid profile viz. total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) of control and drug-treated animals. Phytochemical analysis revealed the presence of phenols, proteins and amino acids, carbohydrates, saponins and diterpenes. The total phenolic content of whole plant hydro alcoholic extract was (1.158mg/100mg), followed by flavonoids (0.745mg/100mg). The extract exhibited a dose dependent anti-hyperlipidemic activity and at dose level 200mg/kg p.o. the extract showed a significant decrease in the levels of serum TC, TG and HDL-C. The present study demonstrated that the extract exhibits a potent lipid lowering activity in diet induced hyperlipidemia which account for some of the medical claims attributed to this plant.

Keywords:

Hyperlipidemia, Solanum virginianum, phytochemical profile, Cholesterol, Triglycerides High density lipoprotein cholesterol