A NEW APPROACH FOR PREPARING SC-514 LOADED PLGA PARTICLES BY SINGLE EMULSION METHOD

Toluleke Oloruntobi Famuyiwa, Joubin Jebelli, Zoey Bowers, Austin Bentley, Davian Caraballo, Paulynice Subtil, James Kwasi Kumi Diaka, Waseem Asghar

Department of Biological Sciences, Florida Atlantic University, College Avenue, Davie, FL, USA

ABSTRACT

Poly (lactic-co-glycolic acid) (PLGA) is a non-toxic or non-injurious subdivision of biodegradable polymer that is not capable of causing immunological rejection. PLGA has been successfully used to encapsulate drugs and deliver drugs in various applications. This high success rate can be linked to the fact that PLGA has been approved by FDA (Food and Drug Administration). SC-514 is a relatively new hydrophobic dug, which has been shown to have anti-cancer effects via inhibition of NF-KB dependent gene expression in cancer cells. SC-514 was encapsulated in PLGA nanoparticles via single-emulsion method. The SC-514 loaded PLGA nanoparticles (diameter=49.4nm) synthesized has the potential to increase the bioavailability of SC-514 drug in prostate cancer treatment. Hence, increasing the therapeutic effect of SC-514 in prostate cancer treatment.

Keywords:

Drug delivery, drug resistance, drug transport. Microscopic imaging, nanotechnology, NF-kB transcription factor, pharmacokinetics