IMPORTANCE OF SOLUBILITY AND SOLUBILITY ENHANCEMENT TECHNIQUES

Manoj Gajanan Bajait*, Roshan Ghatmale, Bhagyashree mundhe

Sandip Institute of Pharmaceutical Sciences, Nashik, Maharastra

ABSTRACT

For a drug to elicit its pharmacological action it should be absorbed from the site of administration. The solubility and Dissolution of drug in GI fluid is the rate determining step in absorption of drug. More than 40% of drug developed by pharmaceutical industry are practically insoluble in water and therefore Enhancement of solubility of practically insoluble drug was the most challenging aspect of drug development. There are various technique available for increasing the solubility of the drug. The technique include physical and chemical modification of drug. This review aimed to compile the information on various solubility enhancement techniques and arrange them in a systematic manner to use as ready reference.

Keywords:

Solubilization, polymorphism, lipophilicity, pharmacology, particle technologies