OLD DRUG WITH NEW MILESTONE: CHLOROQUINE AND HYDROXYCHLOROQUINE IN SARS-COV-2 (COVID-19) WITH MULTIFACETED EFFECTS IN OTHER DISEASES

Barrawaz Aateka Yahya*, Baig Shahajan Shabbir, Dr Bawazir Abubakar Salam

YB. Chavan College of Pharmacy, Aurangabad, Maharastra, India

ABSTRACT

Hydroxychloroquine is one of the oldest and widely used anti-malarial drug which can be beard easily with cost and well leeway, also these drugs have been greet to have efficacy in autoimmune-related diseases like rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine is known to be a disease-modifying antirheumatic drug, for this, it has been approved firstly in the year 1955 by the United state of food and drug administration. Hydroxychloroquine and chloroquine are recently shown several activities like glucose-lowering effects along with prophylactic use, Dyslipidemia, anticancer, anti-platelet, antithrombotic, antiviral, endothelial dysfunction. Because of the recent outbreak of world has diverted towards these molecules and initiated global clinical trials on Chloroquine and Hydroxychloroquine. So this article focused on the multifaceted effect of Hydroxychloroquine and chloroquine mainly concerning corona. Considering the anti-hyperglycemic potential, anti-inflammatory activity and, pleiotropic effects such as lipid-lowering action, anti-platelet action, antithrombotic action, endothelial dysfunctioning, orbital sarcoidosis, and nephroprotective action, HCQ may emerge as a cost-effective therapeutic option for uncontrolled diabetes patients in alone therapy or combinations. Chloroquine and Hydroxychloroquine have been proved its efficacy towards the recent spread of pandemic disease novel coronavirus.

Keywords:

Hydroxychloroquine, Diabetes mellitus, Severe Acute Respiratory Syndrome Coronavirus-2, Disease-Modifying Antirheumatic Drugs, COVID 19.